A deformed and/or non-healing tibia bone, often associated with Neurofibromatosis type 1 (NF1).
More Information on Congenital Pseudarthrosis of the Tibia
CPT, which causes a deformity of the leg, often shortening of the leg and a non-healing fracture, has been troublesome for surgeons to treat. Oftentimes patients have undergone multiple procedures in childhood which has left the leg quite damaged and the ankle not functional. As a result, amputation is offered to the families of these children. This has all changed over the past several years with combining treatment in the Cross Union Technique.
Most (>80%) children with congenital pseudarthrosis of the tibia suffer from Neurofibromatosis Type 1.
CPT may be diagnosed on plain x-rays based on a very specific deformity of the tibia. NF1 may be diagnosed with a genetic blood test.
Utilizing pre-surgical Zolendronic Acid intravenously, combined with a surgery that includes: excising all the tissue causing the non-healing bone, freshening the bone edges, placing a very large bone graft from the patient’s pelvis (a unique and difficult procedure) between the tibia and fibula, utilizing Bone Morphogenic protein, and a periosteal graft from the pelvic lining combined with a growing rod in the bone and a plate to hold it for 6 months. All of this has allowed for complete healing of the tibia in this population. The surgery also allows the ankle to move and preserves the ankle function.